Contact Us

  • Rhett Kovall, PhD
  • Associate Professor of Molecular Genetics
  • Academic Office:
    University of Cincinnati College of Medicine
    Department of Molecular Genetics, Biochemistry and Microbiology
    Cincinnati, OH 45267-0524
  • Phone: 513-558-4631
  • Email: rhett.kovall@uc.edu

    Education/Credentials:

  • B.A.: University of Colorado, 1992
  • Ph.D.: University of Oregon, Institute of Molecular Biology, 1998

Post Graduate Training/Education:

  • Postdoctoral Training
    1999-2004, Columbia University Biochemistry & Molecular Biophysics, New York, NY, Postdoctoral fellow in the laboratory of Dr. Wayne A. Hendrickson.

Peer Reviewed Publications (in chronological order):

  • Collins, K. J., Yuan, Z., & Kovall, R. A. (2014). Structure and function of the CSL-KyoT2 corepressor complex: a negative regulator of notch signaling. . Structure (London, England : 1993) , 22 (1) , 70-81.
  • Su, S., Panmanee, W., Wilson, J. J., Mahtani, H. K., Li, Q., Vanderwielen, B. D., Makris, T. M., Rogers, M., McDaniel, C., Lipscomb, J. D., Irvin, R. T., Schurr, M. J., Lancaster, J. R., Kovall, R. A., & Hassett, D. J. (2014). Catalase (KatA) plays a role in protection against anaerobic nitric oxide in Pseudomonas aeruginosa. . PloS One , 9 (3) , e91813.
  • Yuan, Z., Friedmann, D. R., Vanderwielen, B. D., Collins, K. J., & Kovall, R. A. (2012). Characterization of CSL (CBF-1, Su(H), Lag-1) Mutants Reveals Differences in Signaling Mediated by Notch1 and Notch2. . The Journal of Biological Chemistry , 287 (42) , 34904-16.
  • Kovall, Rhett A (2012). In notch, one ANK repeat is not like the other. . Structure (London, England : 1993) , 20 (2) , 202-4.
  • Maier, D., Kurth, P., Schulz, A., Russell, A., Yuan, Z., Gruber, K., Kovall, R. A., & Preiss, A. (2011). Structural and functional analysis of the repressor complex in the Notch signaling pathway of Drosophila melanogaster. . Molecular Biology of the Cell , 22 (17) , 3242-52.
  • VanderWielen, B. D., Yuan, Z., Friedmann, D. R., & Kovall, R. A. (2011). Transcriptional repression in the Notch pathway: thermodynamic characterization of CSL-MINT (Msx2-interacting nuclear target protein) complexes. . The Journal of Biological Chemistry , 286 (17) , 14892-902.
  • Bahassi, E. M., Yin, M., Robbins, S. B., Li, Y., Conrady, D. G., Yuan, Z., Kovall, R. A., Herr, A. B., & Stambrook, P. J. (2011). A human cancer-predisposing polymorphism in Cdc25A is embryonic lethal in the mouse and promotes ASK-1 mediated apoptosis. . Cell Division , 6 (1) , 4.
  • Kurth, P., Preiss, A., Kovall, R. A., & Maier, D. (2011). Molecular analysis of the notch repressor-complex in Drosophila: characterization of potential hairless binding sites on suppressor of hairless. . PloS One , 6 (11) , e27986.
  • Conrady, D. G., Flagler, M. J., Friedmann, D. R., Vander Wielen, B. D., Kovall, R. A., Weiss, A. A., & Herr, A. B. (2010). Molecular basis of differential B-pentamer stability of Shiga toxins 1 and 2. . PloS One , 5 (12) , e15153.
  • Kovall, R. A., & Blacklow, S. C. (2010). Mechanistic insights into Notch receptor signaling from structural and biochemical studies. . Current Topics in Developmental Biology , 92 , 31-71.
  • Friedmann, D. R., & Kovall, R. A. (2010). Thermodynamic and structural insights into CSL-DNA complexes. . Protein Science : A Publication of the Protein Society , 19 (1) , 34-46.
  • Kovall, R A (2008). More complicated than it looks: assembly of Notch pathway transcription complexes. . Oncogene , 27 (38) , 5099-109.
  • Friedmann, D. R., Wilson, J. J., & Kovall, R. A. (2008). RAM-induced allostery facilitates assembly of a notch pathway active transcription complex. . The Journal of Biological Chemistry , 283 (21) , 14781-91.
  • Kovall, Rhett A (2007). Structures of CSL, Notch and Mastermind proteins: piecing together an active transcription complex. . Current Opinion in Structural Biology , 17 (1) , 117-27.
  • Wilson, J. J., & Kovall, R. A. (2006). Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA. . Cell , 124 (5) , 985-96.
  • Kovall, R. A., & Hendrickson, W. A. (2004). Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA. . The EMBO Journal , 23 (17) , 3441-51.
  • Min, K. C., Kovall, R. A., & Hendrickson, W. A. (2003). Crystal structure of human alpha-tocopherol transfer protein bound to its ligand: implications for ataxia with vitamin E deficiency. . Proceedings of the National Academy of Sciences of the United States of America , 100 (25) , 14713-8.
  • Kovall, R. A., & Matthews, B. W. (1999). Type II restriction endonucleases: structural, functional and evolutionary relationships. . Current Opinion in Chemical Biology , 3 (5) , 578-83.
  • Kovall, R. A., & Matthews, B. W. (1998). Structural, functional, and evolutionary relationships between lambda-exonuclease and the type II restriction endonucleases. . Proceedings of the National Academy of Sciences of the United States of America , 95 (14) , 7893-7.
  • Rhett Kovall and Brian W. Matthews (1997). Toroidal Structure of Lambda-Exonuclease . Science , 277 (5333) , 1824-1827.

    Research Grants:

  • 000076 Leukemia Research Foundation. Structure-function of Notch-CSL Transcription Complexes: A Structural Basis for Developing Anti-Leukemia Drugs, PI, Closed.
  • R01 CA120199 National Cancer Institute. Structure and Function of CSL, the Transcriptional Regulator in the Notch Pathway, PI, Closed.
  • 1278-10 Leukemia & Lymphoma Society. Biophysical Characterization of Notch Pathway Transcription Complexes, PI, Active.
  • MDA 135618 Muscular Dystrophy Association. Analysis of Notch Transcriptional Mechanisms Required for Muscle Regeneration, PI, Closed.
  • 11PRE7070002 American Heart Association - National Chapter. Thermodynamic, in Vivo, and Structural Analysis of the Notch Pathway CSL-KyoT2 Corepressor Complex, Collaborator, Active.
  • R01CA178974 National Cancer Institute. Molecular mechanisms of transcriptional regulation in the Notch pathway, PI, Active.
  • 13PRE15570002 American Heart Association - National Chapter. Structure and Function of the MINT/NCoR complex, a novel phosphorylation mechanism that regulates Notch signaling, Collaborator, Active.