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Anil 
Menon
, Ph.D.
Professor

B.Sc., 1979 , University of Bombay , Bombay , India

PhD, 1987 , University Of Cincinnati , Cincinnati , OH

Postdoc , Harvard University , Cambridge , MA

There are several areas of research in our laboratory mainly aimed at understanding normalcy and disease in the cardiovascular system. For example, the goal of one project is to understand the role of �stress� molecules on the development and remodeling of the cardiovascular system in mammals. Another project has been designed to study the regulation of the genes and proteins that are involved in information transfer across the maternal fetal interface. The transporters are of particular interest in this respect include sodium and water channels (aquaporins). We study the transcriptional and post-transcriptional regulation of these genes and the proteins that they encode, and are especially interested in understanding the role that these genes may play in human diseases such as hypertension, diabetes and obesity.

Selected Publications:
  • Kawedia, J.D., Jiang, M., Kulkarni, A., Waechter, H.E., Matlin, K.S., Pauletti, G.M., and Menon, A.G. (2008) The protein kinase A pathway contributes to Hg2+-induced alterations in phosphorylation and subcellular distribution of occludin associated with increased tight junction permeability of salivary epithelial cell monolayers. J Pharmacol Exp Ther, Sept, 326(3): 829-37.
  • Kawedia, J.D., Nieman, M.L., Boivin, G.P., Melvin, J.E., Kikuchi, K., Hand A.R., Lorenz, J.N., and Menon, A.G. (2007) Interaction between transcellular and paracellular water transport pathways through Aquaporin 5 and the tight junction complex. Proc Natl Acad Sci USA, Feb 27, 104(9): 3621-6.
  • Ingraham, S.E., Lynch, R.A., Surti, U., Rutter, J.L., Buckler, A.J., Khan, S.A., Menon, A.G., and Lepont, P. (2006) Identification and characterization of novel human transcripts embedded within HMGA2 in t(12;14)(q15;q24.1) uterine leiomyoma. Mutat Res, December, 602(1-2): 43-53.
  • Tong, Q., Menon, A.G., and Stockand, J.D. (2006) Functional polymorphisms in the α-subunit of the human epithelial Na+ channel increase activity. Am. J. Physiol. 290 (4):821-827.
  • Yang, F., Kawedia, J.D. and Menon, A.G. (2003) Cyclic AMP Regulates Aquaporin 5 Expression at both Transcriptional and Post-transcriptional Levels through a Protein Kinase A Pathway. J Biol Chem. 278(34):32173-80.
  • Krane, C.M., Melvin, J.E., Nguyen, H., Richardson, L., Towne, J.E., Doetschman, T., and Menon, A.G. (2001) Salivary Gland Acinar Cells From Aquaporin 5 Deficient Mice Have Decreased Membrane Permeability and Altered Cell Volume Regulation. J. Biol. Chem. June 29; 276(26):23413-23420.
  • Towne, J.E., Krane, C.M., Bachurski, C.J., and Menon, A.G. (2001) Tumor Necrosis Factor-alpha Inhibits Aquaporin 5 Expression in Mouse Lung Epithelial Cells. J. Biol. Chem. June 1; 276(22):18657-64.
  • Krane, C.M., Fortner, C.N., Hand, A.R., McGraw, D.W., Lorenz, J.N., Wert, S.E., Towne, J.E., Paul, R.J., Whitsett, J.A., and Menon, A.G. (2001) Aquaporin 5 Deficient Mice are Hyperresponsive to Cholinergic-Stimulation: a novel pathway for Bronchoconstriction. Proc. Natl. Acad. Sci. U.S.A. Nov 20;98 (24):14114-9.
  • Nebert, D.W. and Menon, A.G. (2001) Pharmacogenomics, Ethnicity, and Susceptibility Genes. The Pharmacogenomics Journal (Nature Journals) May 2001; 1, 19-22.

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