Advanced Macromolecular Crystallography

26 MG 823
3 graduate credits

Course Director: Dr. Andrew Herr

This is an in-depth course covering both theory and practical applications of modern X-ray crystallography. Topics to be covered include diffraction theory, space groups, the electron density equation, the phase problem, statistical error analysis, data processing, and techniques for phasing such as multiple isomorphous replacement, multiwavelength anomalous diffraction, and molecular replacement. The course will feature lectures by faculty as well as hands-on sessions designed to help students learn basic techniques of crystallography, and is intended for those students who will be actively pursuing crystallography as a research endeavor.

Prerequisites: Molecular Biology of the Cell I: Proteins and Enzymes and Proteins: Structure, Function, and Engineering